Hypoxia has long been linked to the Warburg effect, yet the underlying mechanism remains largely unclear. It is also not known if lncRNAs are involved in the contribution of hypoxia to the Warburg effect. Here we show that lincRNA-p21 is a hypoxia-responsive lncRNA and is essential for hypoxia-enhanced glycolysis. Hypoxia/HIF-1α-induced lincRNA-p21 is able to bind HIF-1α and VHL and thus

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fr.4 995 krRek.7 300:- Se priset! Duschhörn INR Linc Niagara · Duschhörn INR Linc Niagara. fr.6 714 krRek.8 290:- Se priset! Long intergenic noncoding RNAs, or lincRNAs, are long RNA transcripts that have been identified in mammalian genomes by bioinformatics analysis of transcriptomic data.

However, our understanding of lincRNA abundance and function remains very limited especially for agriculturally important plants. Long noncoding RNAs (lncRNAs) represent a class of transcribed RNA molecules that are longer than 200 nucleotides and yet do not encode proteins.

Mar 18, 2019 Long intergenic non-coding RNAs (lincRNAs) have been considered to play a key regulatory role in various biological processes.

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Large intergenic noncoding RNAs (lincRNAs) are still poorly functionally characterized. We analyzed the genetic and epigenetic regulation of human lincRNA expression in the GenCord collection by using three cell types from 195 unrelated European individuals.

SO Accession: SO:0001463 (SOWiki). Definition: Long, intervening non-coding RNA. A transcript that does not overlap within the In the most recent statistics from the GENCODE project (v29, October 2018), the human genome contains 23,643 non-coding RNA (ncRNA) genes, surpassing Using the lincRNA sequences, we set out to determine the functional role of lincRNAs using loss-of-function experiments. Unlike correlation analysis, these In this issue, Yoon et al. (2012) reveal that HuR influences decay of a long noncoding RNA (lincRNA-p21) that in turn hybridizes to mRNA targets and represses Feb 6, 2014 We confirmed adipocytes and monocytes as potential cell-sources of selective lipopolysaccharide-regulated lincRNAs, and 2 of these, linc- Oct 1, 2014 Of these, lincRNA-VLDLR (linc-VLDLR) was significantly upregulated in malignant hepatocytes. Exposure of HCC cells to diverse anticancer Sep 29, 2015 LincRNA-p21 is a downstream long non-coding RNA (lncRNA) transcript of p53.

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INR Duschhörna LINC 13 Flex Vänster · Info · INR Duschhörna LINC 13 Flex Vänster. INR. av NM Fischer · 2018 · Citerat av 28 — for breaking RNA atom-ion interactions) is found to tion shell to the RNA, diffuse Mg2+ ions that bind via mul- LINCS (71,72) algorithm. I den här typen av RNA står "linc" för long intergenic non-coding, vilket betyder att det är RNA som långt, men ändå inte kodar för något protein. Next-generation sequencing reveals two populations of damage-induced small RNAs at endogenous DNA double-strand breaks2018Ingår i: Nucleic Acids Svensktillverkade LINC 13 Original finns i fasta standardmått men också i måttanpassat DuschhÃ¶rna med trendig och industriell kÃ¤nsla, 6 mm hÃ¤rdat glas.
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Long intergenic non-coding RNAs (lincRNAs) are defined as RNA transcripts that are longer than 200 nucleotides. By definition, these RNAs must not have open reading frames that encode proteins. Many of these transcripts are encoded by RNA polymerase II, are spliced, and are poly-adenylated. This final fact indicates that there is a trove of information about lincRNAs in databases such as the

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